Senior Backend Engineer, AI & Bioinformatics (TypeScript)

Sequencing.com is building the interface between humanity and its DNA using clinical-grade whole genome sequencing, AI, and a rapidly expanding ecosystem of genomic applications. They are seeking a Senior Backend Engineer with expertise in AI and bioinformatics to design and build distributed services, genomic reasoning engines, and retrieval systems.

• Design and build the production AI systems powering Sequencing AI
• Develop distributed backend services, genomic reasoning engines, and retrieval systems that combine bioinformatics with modern AI
• Serve as the bioinformatics expert on the AI Team, helping shape how genomic knowledge is represented, retrieved, reasoned over, and validated throughout the platform
• Design how AI represents, retrieves, and reasons over genomic knowledge to deliver accurate, explainable, and scientifically grounded responses
• Build scalable services that enable AI to accurately reason over genes, variants, diseases, medications, and scientific literature
• Design high-performance data models, indexing strategies, and storage architectures across PostgreSQL, Qdrant, Redis, DuckDB, and Apache Spark
• Develop guardrails and deterministic reasoning layers that keep AI responses scientifically accurate, explainable, and grounded in genomic evidence
• Translate complex bioinformatics and genomic knowledge into scalable, production-ready software
• Collaborate with Senior Backend Engineers to architect AI systems that are fast, reliable, and built to scale
• Work closely with the Bioinformatics team to integrate genomic annotations, interpretation logic, and scientific knowledge into the AI platform
• Continuously improve the platform's scientific accuracy, performance, and capabilities as AI and genomic science evolve

• 5+ years designing, building, and operating production backend systems at scale
• Expert-level TypeScript with experience owning production services end to end
• Strong distributed systems fundamentals
• Hands-on experience building large-scale data processing systems using Apache Spark and processing very large datasets
• Deep experience designing high-performance data architectures using PostgreSQL, DuckDB, Redis, and similar technologies
• Experience building distributed, event-driven systems using AWS SQS, RabbitMQ, or BullMQ
• Experience building production AI systems, including retrieval architectures, vector databases, LLM APIs, and AI evaluation
• Deep expertise in human whole genome sequencing and genomic interpretation
• Extensive experience working with VCFs, genomic annotations, and variant interpretation
• Strong knowledge of ClinVar, dbSNP, gnomAD, HGVS nomenclature, transcript databases, and other core genomic resources
• Experience building production software that applies bioinformatics and genomic knowledge to real-world clinical or consumer genomics applications
• A passion for genetics and applying complex genomic science to build AI systems that help people better understand and improve their health

• Comprehensive medical, dental, and vision insurance coverage
• 401(k) with company matching
• Paid time off (PTO)
• Paid volunteer time off
• Fully remote work with home office stipend
• Parental bonding leave
• Clinical-grade whole genome sequencing for you and your family (private and confidential)